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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)
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Thereby, as mentioned, it may be relevant the described immediate gross disappearance of the swollen brain presentation, and microscopically only a few karyopyknotic neurons upon administration of the BPC 157 regimens, given locally at the swollen brain, or intragastrically or intraperitoneally, thus, evidencing a consistent BPC 157 effect, as shown by the direct recording
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